منابع مشابه
Molecular Analysis of Precursor Lesions in Familial Pancreatic Cancer
BACKGROUND With less than a 5% survival rate pancreatic adenocarcinoma (PDAC) is almost uniformly lethal. In order to make a significant impact on survival of patients with this malignancy, it is necessary to diagnose the disease early, when curative surgery is still possible. Detailed knowledge of the natural history of the disease and molecular events leading to its progression is therefore c...
متن کاملIncreased Prevalence of Precursor Lesions in Familial Pancreatic Cancer Patients.
PURPOSE: Histologic findings in 51 pancreata resected from patients with a strong family history of pancreatic cancer were compared with the findings in 40 pancreata resected from patients with sporadic pancreatic cancer. None of the patients in the familial group had a known inherited syndrome other than familial pancreatic cancer. EXPERIMENTAL DESIGN: Precursor lesions, including pancreatic i...
متن کاملPrecursor Lesions for Sporadic Pancreatic Cancer: PanIN, IPMN, and MCN
Pancreatic cancer is still a dismal disease. The high mortality rate is mainly caused by the lack of highly sensitive and specific diagnostic tools, and most of the patients are diagnosed in an advanced and incurable stage. Knowledge about precursor lesions for pancreatic cancer has grown significantly over the last decade, and nowadays we know that mainly three lesions (PanIN, and IPMN, MCN) a...
متن کاملCarcinogenesis of Pancreatic Adenocarcinoma: Precursor Lesions
Pancreatic adenocarcinoma displays a variety of molecular changes that evolve exponentially with time and lead cancer cells not only to survive, but also to invade the surrounding tissues and metastasise to distant sites. These changes include: genetic alterations in oncogenes and cancer suppressor genes; changes in the cell cycle and pathways leading to apoptosis; and also changes in epithelia...
متن کاملPancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid of primary cilia.
Primary cilia have been proposed to participate in the modulation of growth factor signaling pathways. In this study, we determined that ciliogenesis is suppressed in both pancreatic cancer cells and pancreatic intraepithelial neoplasia (PanIN) lesions in human pancreatic ductal adenocarcinoma (PDAC). Primary cilia were absent in these cells even when not actively proliferating. Cilia were also...
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ژورنال
عنوان ژورنال: Gut and Liver
سال: 2008
ISSN: 1976-2283,2005-1212
DOI: 10.5009/gnl.2008.2.3.137